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Yasuni Nakanuma Selected Research

Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)

1/2022Identification of circulating microRNAs as potential biomarkers for hepatic necroinflammation in patients with autoimmune hepatitis.
1/2021Interferon-induced protein with tetratricopeptide repeats 3 may be a key factor in primary biliary cholangitis.
1/2020Increased p16INK4a-expressing senescent bile ductular cells are associated with inadequate response to ursodeoxycholic acid in primary biliary cholangitis.
8/2018Effect of deferred or no treatment with ursodeoxycholic acid in patients with early primary biliary cholangitis.
1/2018An impaired biliary bicarbonate umbrella may be involved in dysregulated autophagy in primary biliary cholangitis.
1/2017Bile Acids and Deregulated Cholangiocyte Autophagy in Primary Biliary Cholangitis.
10/2015In recurrent primary biliary cirrhosis after liver transplantation, biliary epithelial cells show increased expression of mitochondrial proteins.
9/2015A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis.
8/2015Autoantibody status and histological variables influence biochemical response to treatment and long-term outcomes in Japanese patients with primary biliary cirrhosis.
6/2015Biochemical responses to bezafibrate improve long-term outcome in asymptomatic patients with primary biliary cirrhosis refractory to UDCA.
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Yasuni Nakanuma Research Topics

Disease

95Neoplasms (Cancer)
06/2022 - 05/2002
67Cholangiocarcinoma
10/2018 - 10/2002
51Biliary Liver Cirrhosis (Primary Biliary Cirrhosis)
01/2022 - 01/2002
39Carcinoma (Carcinomatosis)
06/2022 - 02/2003
24Fibrosis (Cirrhosis)
10/2017 - 12/2003
24Sclerosing Cholangitis
03/2016 - 07/2003
23Hepatocellular Carcinoma (Hepatoma)
02/2018 - 01/2004
22Inflammation (Inflammations)
01/2016 - 08/2002
19Cholangitis
01/2017 - 06/2002
16Hepatitis
01/2019 - 07/2002
16Adenocarcinoma
03/2017 - 09/2003
13Carcinogenesis
06/2016 - 02/2006
12Carcinoma in Situ
06/2022 - 12/2004
12Immunoglobulin G4-Related Disease
09/2016 - 08/2007
10Non-alcoholic Fatty Liver Disease
11/2015 - 04/2007
9Autoimmune Pancreatitis
03/2017 - 02/2005
9Necrosis
01/2016 - 07/2002
8Autoimmune Hepatitis
01/2022 - 08/2005
8Neoplasms, Cystic, Mucinous, and Serous
03/2017 - 09/2006
7Insulin Resistance
11/2015 - 01/2007
6Pancreatic Neoplasms (Pancreatic Cancer)
02/2015 - 01/2009
6Metaplasia
12/2012 - 05/2002
6Neoplasm Metastasis (Metastasis)
10/2009 - 08/2004
6Pancreatitis
07/2008 - 02/2005
5Fatty Liver
11/2015 - 01/2007
5Alcoholic Liver Cirrhosis (Alcoholic Cirrhosis)
05/2015 - 01/2002
5Cysts
01/2014 - 02/2004
5Biliary Atresia
01/2012 - 10/2007
5Liver Diseases (Liver Disease)
01/2012 - 08/2004
4Autoimmune Diseases (Autoimmune Disease)
01/2022 - 06/2002
4Gallbladder Neoplasms (Gallbladder Cancer)
06/2021 - 03/2012
4Lymphatic Metastasis
07/2018 - 09/2003
4Autosomal Recessive Polycystic Kidney (Polycystic Kidney Disease, Infantile, Type I)
10/2017 - 02/2004
4Klatskin Tumor
02/2016 - 08/2007
4Alcoholic Fatty Liver
06/2015 - 11/2007
4Focal Nodular Hyperplasia
11/2013 - 02/2009
4Digestive System Diseases
03/2012 - 07/2003
4Polycystic Kidney Diseases (Polycystic Kidney Disease)
12/2011 - 02/2004
4Infections
12/2011 - 10/2002
4Mucinous Adenocarcinoma (Mucinous Carcinoma)
06/2010 - 02/2006
4Liver Cirrhosis (Hepatic Cirrhosis)
02/2010 - 10/2006
3Adenoma (Adenomas)
02/2022 - 03/2009

Drug/Important Bio-Agent (IBA)

27MucinsIBA
02/2017 - 05/2002
24Bile Pigments (Bilin)IBA
06/2022 - 04/2005
22Immunoglobulin G (IgG)IBA
09/2016 - 02/2005
21Proteins (Proteins, Gene)FDA Link
01/2021 - 07/2003
16Immunoglobulins (Immunoglobulin)IBA
03/2016 - 10/2007
13CytokinesIBA
01/2012 - 01/2003
11Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
06/2010 - 03/2005
10AntigensIBA
06/2020 - 06/2002
9Biological ProductsIBA
11/2019 - 09/2003
9gadolinium ethoxybenzyl DTPAFDA Link
02/2018 - 09/2010
8LigandsIBA
05/2014 - 06/2005
8Cyclin-Dependent Kinase Inhibitor p16IBA
03/2014 - 07/2008
7Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2014 - 10/2007
6AntibodiesIBA
01/2017 - 06/2002
6AutoantibodiesIBA
08/2015 - 01/2003
6Polycomb-Group ProteinsIBA
03/2015 - 08/2008
6ChemokinesIBA
02/2014 - 02/2010
6EnzymesIBA
10/2013 - 11/2007
6Neural Cell Adhesion Molecules (Neural Cell Adhesion Molecule)IBA
09/2013 - 04/2008
6Transforming Growth Factor beta1 (TGF beta 1)IBA
07/2010 - 04/2005
5Biomarkers (Surrogate Marker)IBA
01/2022 - 01/2012
5Peptides (Polypeptides)IBA
02/2018 - 08/2006
5Serum Amyloid A Protein (Serum Amyloid A)IBA
09/2015 - 01/2012
5Phenobarbital (Luminal)FDA Link
07/2014 - 08/2002
5DNA (Deoxyribonucleic Acid)IBA
01/2014 - 12/2002
5Cyclin D1IBA
01/2014 - 12/2004
5Messenger RNA (mRNA)IBA
05/2013 - 09/2003
5Pathogen-Associated Molecular Pattern MoleculesIBA
12/2012 - 06/2007
5Keratin-7 (Cytokeratin 7)IBA
12/2012 - 02/2003
5beta CateninIBA
11/2012 - 08/2007
5SteroidsIBA
09/2012 - 12/2002
5Keratin-20 (Cytokeratin 20)IBA
08/2011 - 11/2006
5Cadherins (E-Cadherin)IBA
05/2010 - 08/2007
4CateninsIBA
02/2018 - 10/2009
4Fatty Acids (Saturated Fatty Acids)IBA
06/2015 - 11/2007
4PAceinIBA
02/2015 - 02/2013
4SolventsIBA
11/2014 - 01/2014
4gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA
11/2014 - 08/2003
4Adrenal Cortex Hormones (Corticosteroids)IBA
07/2014 - 08/2007
4Oxidoreductases (Dehydrogenase)IBA
06/2014 - 05/2003
4Chemokine CX3CL1IBA
10/2013 - 03/2005
4Small Interfering RNA (siRNA)IBA
02/2013 - 12/2009
4Triglycerides (Triacylglycerol)IBA
01/2012 - 01/2007
4Toll-Like Receptors (Toll-Like Receptor)IBA
08/2011 - 11/2003
4Keratins (Keratin)IBA
02/2011 - 04/2007
4Transforming Growth Factor beta (TGF-beta)IBA
07/2010 - 10/2002
4PPAR gammaIBA
06/2010 - 06/2005
4Reactive Oxygen Species (Oxygen Radicals)IBA
02/2010 - 08/2002
4NF-kappa B (NF-kB)IBA
02/2009 - 06/2007
4Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
07/2008 - 01/2003
3Ursodeoxycholic Acid (Urso)FDA LinkGeneric
01/2020 - 06/2015
3CarbohydratesIBA
10/2018 - 01/2014
3wisteria lectinIBA
02/2017 - 07/2010
3Pyruvate Dehydrogenase Complex (Dehydrogenase Complex, Pyruvate)IBA
01/2017 - 06/2002

Therapy/Procedure

16Therapeutics
02/2017 - 12/2002
13Hepatectomy
08/2016 - 01/2004
6Liver Transplantation
10/2015 - 08/2005
3Cholecystectomy
10/2021 - 09/2013